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1

Introduction to Biological and Small Molecule Drug Research and Development || Similarities and differences in the discovery and use of biopharmaceuticals and small-molecule chemotherapeutics

Year:

2013

Language:

english

File:

PDF, 1.48 MB

english, 2013

2

Introduction to Biological and Small Molecule Drug Research and Development || The structure and business of biopharmaceutical companies including the management of risks and resources

Year:

2013

Language:

english

File:

PDF, 1.32 MB

english, 2013

3

Development of GPIIb/IIIa antagonists as antithrombotic drugs

Andrew J. Nichols, Robert R. Ruffolo Jr, William F. Huffman, George Poste, James Samanen

Journal:

Trends in Pharmacological Sciences

Year:

1992

Language:

english

File:

PDF, 747 KB

english, 1992

4

Pluripotential amino acids I. (L)-p-dihydroxyborylphenylalanine (L-Bph) as a precursor of L-Phe and L-Tyr containing peptides; specific tritiation of L-Phe-containing peptides at a final step in synthesis

David C. Roberts, Kohji Suda, James Samanen, D.S. Kemp

Journal:

Tetrahedron Letters

Year:

1980

Language:

english

File:

PDF, 236 KB

english, 1980

5

Potent non-peptide fibrinogen receptor antagonists which present an alternative pharmacophore

Ku, Thomas W., Miller, William H., Bondinell, William E., Erhard, Karl F., Keenan, Richard M., Nichols, Andrew J., Peishoff, Catherine E., Samanen, James M., Wong, Angela S., Huffman, William F.

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 430 KB

english, 1995

6

Discovery of Potent Nonpeptide Vitronectin Receptor (α V β 3 ) Antagonists

Keenan, Richard M., Miller, William H., Kwon, Chet, Ali, Fadia E., Callahan, James F., Calvo, Raul R., Hwang, Shing-Mei, Kopple, Kenneth D., Peishoff, Catherine E., Samanen, James M., Wong, Angela S.,

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 241 KB

english, 1997

7

Phenylbutyrates as potent, orally bioavailable vitronectin receptor (integrin αvβ3) antagonists

William H Miller, Peter J Manley, Russell D Cousins, Karl F Erhard, Dirk A Heerding, Chet Kwon, Stephen T Ross, James M Samanen, Dennis T Takata, Irene N Uzinskas, Catherine C.K Yuan, R.Curtis Haltiwa

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 161 KB

english, 2003

8

Refinement of a molecular model of angiotensin II (AII) employed in the discovery of potent nonpeptide antagonists

James M. Samanen, Catherine E. Peishoff, Richard M. Keenan, Joseph Weinstock

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 400 KB

english, 1993

9

Combinatorial chemistry. Use of an intramolecular ruthenium catalyzed olefin/alkyne metathesis reaction in tandem with a Diels-Alder cycloaddition reaction to construct functionalized hexahydroisoindoles

Dirk A. Heerding, Dennis T. Takata, Chet Kwon, William F. Huffman, James Samanen

Journal:

Tetrahedron Letters

Year:

1998

Language:

english

File:

PDF, 243 KB

english, 1998

10

SYNTHESIS OF A S-4-CARBOXYPHENYLALANINE DERIVATIVE FOR USE IN PEPTIDE SYNTHESIS

Franz, Robert G., Weinstock, Joseph, Calvo, Raul R., Samanen, James, Aiyar, Nambi

Journal:

Organic Preparations and Procedures International

Year:

1994

Language:

english

File:

PDF, 339 KB

english, 1994

11

The role of position four in angiotensin II antagonism: a structure-activity study

Samanen, James, Cash, T., Narindray, D., Brandeis, E., Yellin, T., Regoli, D.

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 631 KB

english, 1989

12

Conformational Preferences in a Benzodiazepine Series of Potent Nonpeptide Fibrinogen Receptor Antagonists

Keenan, Richard M., Callahan, James F., Samanen, James M., Bondinell, William E., Calvo, Raul R., Chen, Lichong, DeBrosse, Charles, Eggleston, Drake S., Haltiwanger, R. Curtis, Hwang, Shing Mei, Jakas

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 459 KB

english, 1999

13

Potent nonpeptide angiotensin II receptor antagonists. 2. 1-(Carboxybenzyl)imidazole-5-acrylic acids

Keenan, Richard M., Weinstock, Joseph, Finkelstein, Joseph A., Franz, Robert G., Gaitanopoulos, Dimitri E., Girard, Gerald R., Hill, David T., Morgan, Tina M., Samanen, James M.

Journal:

Journal of Medicinal Chemistry

Year:

1993

Language:

english

File:

PDF, 2.92 MB

english, 1993

14

Enantioselective routes to protected syn- and anti-.beta.-phenylcysteines

Lago, M. Amparo, Samanen, James, Elliott, John D.

Journal:

Journal of Organic Chemistry

Year:

1992

Language:

english

File:

PDF, 546 KB

english, 1992

15

[Annual Reports in Medicinal Chemistry] Volume 31 || Chapter 10. GPIIb/IIIa Antagonists

Year:

1996

Language:

english

File:

PDF, 716 KB

english, 1996

16

Modulation of vitronectin receptor-mediated osteoclast adhesion by Arg-Gly-Asp peptide analogs: A structure-function analysis

Michael A. Horton, Elaine L. Dorey, Stephen A. Nesbitt, James Samanen, Fadia E. Ali, Jeffrey M. Stadel, Andrew Nichols, Russel Greig, Miep H. Helfrich

Journal:

Journal of Bone and Mineral Research

Year:

1993

Language:

english

File:

PDF, 858 KB

english, 1993

17

Chemical Approaches to Improve the Oral Bioavailability of Peptidergic Molecules

JAMES SAMANEN, GLYNN WILSON, PHILIP L. SMITH, CHAO-PIN LEE, WILLIAM BONDINELL, THOMAS KU, GERALD RHODES, ANDREW NICHOLS

Journal:

Journal of Pharmacy and Pharmacology

Year:

1996

Language:

english

File:

PDF, 1.27 MB

english, 1996

18

1-(Carboxybenzyl)imidazole-5-acrylic acids: potent and selective angiotensin II receptor antagonists

Weinstock, Joseph, Keenan, Richard M., Samanen, James, Hempel, Judith, Finkelstein, Joseph A., Franz, Robert G., Gaitanopoulos, Dimitri E., Girard, Gerald R., Gleason, John G.

Journal:

Journal of Medicinal Chemistry

Year:

1991

Language:

english

File:

PDF, 420 KB

english, 1991

19

Potent, Selective, Orally Active 3-Oxo-1,4-benzodiazepine GPIIb/IIIa Integrin Antagonists

Samanen, James M., Ali, Fadia E., Barton, Linda S., Bondinell, William E., Burgess, Joelle L., Callahan, James F., Calvo, Raul R., Chen, Wenting, Chen, Lichong, Erhard, Karl, Feuerstein, Giora, Heys,

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 139 KB

english, 1996

20

The use of rabbit intestinal permeability as an in vitro assay in the search for orally active GPIIb/IIIa antagonists

James M. Samanen, Chao-Pin Lee, Philip L. Smith, William E. Bondinell, Raul R. Calvo, Dalia R. Jakas, Kenneth A. Newlander, Michael Parker, Irene Uzinskas, Tobias O. Yellin, Andrew J. Nichols

Journal:

Advanced Drug Delivery Reviews

Year:

1997

Language:

english

File:

PDF, 746 KB

english, 1997

21

Biogenetic-type approach to homoerythrina alkaloids

Marino, Joseph P., Samanen, James M.

Journal:

Journal of Organic Chemistry

Year:

1976

Language:

english

File:

PDF, 270 KB

english, 1976

22

The chemistry of prohomoerythrinadienone I.

J.P. Marino, James M. Samanen

Journal:

Tetrahedron Letters

Year:

1973

Language:

english

File:

PDF, 154 KB

english, 1973

23

The p-(methylsulfinyl)benzyl group: a trifluoroacetic acid (TFA)-stable carboxyl-protecting group readily convertible to a TFA-labile group

Samanen, James M., Brandeis, Ester

Journal:

Journal of Organic Chemistry

Year:

1988

Language:

english

File:

PDF, 1.12 MB

english, 1988

24

Mode of Action for Linear Peptide Inhibitors of HIV-1 gp120 Interactions †

Biorn, Alyssa C., Cocklin, Simon, Madani, Navid, Si, Zhihai, Ivanovic, Tijana, Samanen, James, Van Ryk, Donald I., Pantophlet, Ralph, Burton, Dennis R., Freire, Ernesto, Sodroski, Joseph, Chaiken, Irw

Journal:

Year:

2004

Language:

english

File:

PDF, 342 KB

english, 2004

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